74178 DATASHEET PDF

Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.

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Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2.

The current items in your cart are: Is your country not in this list? You will receive an e-mail containing a link to start the recovery procedure within minutes. Lower amounts of 5-hmC have been reported in various cancers including myeloid leukemia and melanoma 13, Have trouble resetting your password? Login No need to login to view prices! The modified base itself is stable in vivo and interacts with various readers including MeCP2 11, The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.

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74178 Datasheet PDF

The same sequence of a base datadheet DNA fragment was generated by PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC5-carboxylcytosine 5-caCor 5-formylcytosine 5-fC.

While 5-fC and 5-caC appear to be short-lived intermediate species, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique functions 10, The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially datqsheet cytosine 5-mC, 5-hmC, 5-caC, 5-fC. Please create a new account with your shipping and billing details if you would like to be able to order or view your discount.

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Find your product Go. TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain and embryonic stem cells 5, 8. Please change your password to something memorable and secure upon logging in. The supporting documents available for this product can be downloaded below. Product has been added to your cart. You will receive an e-mail from us containing your new password in the coming minutes. Furthermore, there is an inverse correlation between levels of 5-hmC and histone H3K9 and H3K27 trimethylation, suggesting a role for 5-hmC in gene activation We are committed to providing you with a productive and privacy-friendly website.

Have you published research involving the use of our products? Please select a country. By proceeding on this website, you agree to the placement of these cookies. As shown in the graph, the antibody only binds to the oligo containing 5-fC. Since then this modification has been discovered in many tissues, with the highest levels found in the brain 9.

Datasheet pdf – 4-BIT SHIFT REGISTER – Unknow

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Please refer to this page. The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers.

Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2. We wish you a successful ! Datasheet Datasheet CST Many cells and tissues contain very low endogenous levels of 5-fC that may fall below the detection limits of this antibody. If so we’d love to hear about it. This product is intended for research purposes only. The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue.

Contact us and we will help you. Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7.

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