compared with a rate of 6–20% in cerebral malaria. Data on the prevalence of HMS is scant, but in areas with intense transmission of malaria. malarial splenomegaly. SIR—Hyper-reactive malarial splenomegaly (HMS) is a form of severe malaria, with a mortality rate that exceeds 50%,1,2 compared with . ABSTRACT. Hyper-reactive malarial splenomegaly (HMS) or Tropical splenomegaly syndrome(TSS), occurs in areas of high transmission of.

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Methods Searching The search strategy was based on the following database sources: She received 4 months of weekly chloroquine mg, but her splenomegaly and cell counts did not improve. Humoral immune responses in the tropical-splenomegaly syndrome in New Guinea.

Hyperreactive malarial splenomegaly in Venezuela. Overall, the drugs used were: She had migrated to the United Kingdom 4 years before.

The hyper-reactive malarial splenomegaly: a systematic review of the literature

The condition is prevalent in certain malarious regions of the Old World, mainly in Africa [ 1 — 5 ]. After 8 months of treatment with chloroquine, his splenomegaly was unchanged. Total and differential white cell counts were carried out for all patients to exclude leukemia.


The most frequent anti-malarial treatments administered in endemic countries were weekly chloroquine [ 22631 – 343749616268 – 71 ] or daily proguanil [ 13255257606471 – 78 ]. Hyperreactive malaria in expatriates returning from sub-Saharan Africa.

Verma S, Aggarwal A. Massive hepatosplenomegaly in a child with malaria. National Center for Biotechnology InformationU. However, the liver tended to progressively enlarge, probably related to persistence of the antigenic stimulus [ 95 ].

A year-old woman from Cote d’Ivoire was hypergeactive for investigation of splenomegaly and pancytopenia. Thirty-six patients had improved and 12 had worsened at the end of the follow-up period, while six were reported as unchanged.

Tropical splenomegaly syndrome

There is a marked erythrophagocytosis and lymphocytic infiltration of the pulp. N Engl J Med. Background Hyper-reactive malarial splenomegaly HMS represents one of the leading causes of massive splenomegaly in malaria-endemic countries [ 1 ].

The search strategy was based on the following database sources: The WBC count was Table 1. Fulminant tropical splenomegaly syndrome. Author information Article notes Copyright and License information Disclaimer.

Tropical splenomegaly syndrome in New Guinea. Her splenomegaly and anemia completely resolved within 2 months. The peptide was conjugated with bovine serum albumin BSA.

The hyper-reactive malarial splenomegaly: a systematic review of the literature

The objective of the study was to determine the incidence of HMS in patients who reported to the Omdurman Tropical Diseases Hospital OMTDH in Sudan and to investigate the basic laboratory and immunological hgperreactive of this condition in these patients. No evidence of chronic malaria.


The search was carried out in March The choice of the drug should consider the local pattern of P. The hyperreactie malarial splenomegaly syndrome in a European: Immunological studies in tropical splenomegaly syndrome.

Another approach to the diagnosis of HMS was a combination of major and minor criteria. Hyperreactive malaria splenomegaly is only hypwrreactive in malaria endemic areas [ 9 ].

ZB conceived of the study, provided major contribution to the study design, revised critically the different versions of the draft manuscript, contributed to performing the systematic review, was in charge of the last version of hyperreactuve manuscript.

Therefore, the presence of Plasmodium in blood is necessary for a further development of the syndrome. Acta Med Acad Sci Hung. Table 1 Summary of patient characteristics and clinical features.

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